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Performing your original search, Vaginal absorption
estriol, in PubMed will retrieve 15
citations. |
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Plasma oestriol following vaginal
administration: morning versus evening insertion and influence of
food.
Heimer GM, Englund DE.
The aim of
this trial was to study the vaginal absorption of oestriol and to
investigate whether morning rather than evening oestriol administration
would produce different plasma oestriol patterns. The influence of food
intake on plasma oestriol levels was also investigated. Nine
post-menopausal women were given 0.5 mg oestriol (ovula supplied by Leo
AB, Sweden) intravaginally every evening for 16 days. Thereafter, 1 mg
oestriol was given every evening for another 5 days, except on treatment
days 18 and 19 when 1 mg oestriol was given in the morning instead.
Venous blood samples were collected at frequent intervals on day 19
(morning administration) and a meal was allowed 4 h later. On the day 21
(evening administration), venous blood samples were taken at frequent
intervals during the night and no meal was given until the next morning.
Plasma concentrations of unconjugated oestriol were measured by means of
a specific radioimmunoassay (RIA). A difference was seen in the plasma
oestriol patterns when the results following morning and evening
administration were compared. However, no significant difference as
regards the total 24-h systemic availability of oestriol was observed. A
minimal increase in plasma oestriol levels was seen after a meal in the
case of both morning and evening intravaginal oestriol administration,
possibly as a result of enterohepatic recirculation.
MeSH Terms:
- Absorption
- Comparative Study
- Estriol/administration & dosage*
- Estriol/blood
- Estriol/metabolism
- Female
- Food*
- Humans
- Kinetics
- Menopause/metabolism
- Middle Aged
- Research Support, Non-U.S. Gov't
- Time Factors
- Vagina/metabolism*
Substances:
PMID: 3784920 [PubMed - indexed for MEDLINE]
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