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Performing your original search, Vaginal absorption
estriol, in PubMed will retrieve 15
citations. |
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Vaginal absorption of two estriol
preparations. A comparative study in postmenopausal
women.
Mattsson LA, Cullberg G.
In a
comparative randomized cross-over study the absorption of a single dose
of 0.5 mg estriol from a vaginal cream or a vaginal suppository
(OvestinR, Organon, The Netherlands) was studied. Eight healthy
postmenopausal women participated and the preparations were given with
an interval of 14 days. Blood sampling was performed twice before
application and then after 1/4, 1/2, 1, 2, 4, 6, 8, 24 and 48 hours.
Serum was analysed for unconjugated and conjugated estriol (E3), FSH and
LH by radio-immunoassay. Considerable interindividual variations in
serum levels of unconjugated E3 were found but mean values were about
equal throughout the study for the two preparations. Peak levels of
0.5-0.6 nmol/l were achieved 1-2 hours after application of the
preparations and after 24 hours no unconjugated E3 was measurable.
Conjugated E3 rose rapidly but within 48 hours serum concentrations
reached baseline levels. A maximum decrease in serum LH levels of about
40% was obtained with both preparations after 6 hours and the return to
baseline within 24 hours indicates a relationship to unconjugated E3.
FSH in serum was maximally suppressed 6-12%. Estriol is thus readily
absorbed by the vaginal route and peak levels of unconjugated E3 after
insertion of 0.5 mg estriol seem to be comparable to those obtained
after 8-12 mg estriol given orally.
Publication Types:
- Clinical Trial
- Randomized Controlled Trial
MeSH Terms:
- Absorption
- Clinical Trials
- Comparative Study
- Estriol/administration & dosage
- Estriol/metabolism*
- Female
- Follicle Stimulating Hormone/blood
- Humans
- Luteinizing Hormone/blood
- Menopause*/drug effects
- Middle Aged
- Suppositories
- Vagina/metabolism*
- Vaginal Creams, Foams and Jellies
Substances:
- Suppositories
- Vaginal Creams, Foams and Jellies
- Estriol
- Luteinizing Hormone
- Follicle Stimulating Hormone
PMID: 6421082 [PubMed -
indexed for MEDLINE]
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