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Performing your original search, Vaginal absorption
estriol, in PubMed will retrieve 15
citations. |
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The vaginal absorption of
oestrogens in post-menopausal women.
Punnonen R,
Vilska S, Gronroos M, Rauramo L.
Serum E1, E2 and E3
concentrations and E2/E1 ratio were measured after vaginal application
of conjugated oestrogens, micronized 17 beta-oestradiol and oestriol.
2.4 mg of conjugated oestrogens caused a prompt elevation in the serum
E1 concentration; the E2 level changed only slightly. After vaginal
application of 2 mg micronized 17 beta-oestradiol the main serum
oestrogen is E2 and the conversion of E2 to E1, as in oral
administration, does not occur. A significant elevation in the serum E3
concentration was noted 2 h after the vaginal application of 0.5 mg
oestriol. The E2/E1 ratio changed little after the application of
conjugated oestrogens but increased considerably after the vaginal
administration of 2 mg micronized 17 beta-oestradiol.
MeSH Terms:
- Aged
- Comparative Study
- Estradiol/blood
- Estradiol/metabolism*
- Estriol/blood
- Estriol/metabolism*
- Estrone/blood
- Estrone/metabolism
- Female
- Humans
- Menopause*
- Middle Aged
- Time Factors
- Vagina/metabolism*
Substances:
- Estriol
- Estradiol
- Estrone
PMID: 7231202 [PubMed - indexed for MEDLINE]
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