| Title: |
The oxidative metabolism of estrogen modulates response
to ERT/HRT in postmenopausal women. |
| Authors: |
Armamento-Villareal,
Reina C.1 rvillare@im.wustl.edu
Napoli,
Nicola1
Klug,
Thomas2
Civitelli,
Roberto1 |
| Source: |
BONE;
Sep2004, Vol. 35 Issue 3, p682-688, 7p |
| Document
Type: |
Article |
| Subject
Terms: |
*ESTROGEN
*HYDROXYLATION
*MENOPAUSE
*METABOLISM
*X-rays |
| Author-Supplied
Keywords: |
Osteoporosis
Bone
densitometry
Menopause
Pharmacogenomics
Estrogen
Language
of Keywords: English; German |
| Abstract: |
We have previously
demonstrated that estrogen metabolism is one of the determinants of bone
density after menopause. Increased hydroxylation to relatively
nonestrogenic metabolites 2-hydroxyestrone (2OHE<sub>1</sub>)
and 2-methoxyestrone (2MeOE<sub>1</sub>) was associated with
low bone mineral density (BMD), while increased hydroxylation to the
potent 16α-hydroxyestrone (16αOHE<sub>1</sub>) and weakly
estrogenic estriol (E<sub>3</sub>)
was associated with higher BMD. In this study, we tested the hypothesis
that response to estrogen–hormone replacement
therapy (ERT/HRT) is also related to individual
differences in estrogen metabolism. Urinary estrogen metabolites were
measured in 310 postmenopausal women using ESTRAMET enzyme immunoassay
kit. Of these, 163 were on HRT with conjugated equine estrogen (CEE) and
medroxyprogesterone acetate (MPA, Premarin™ and Provera™) or ERT with
conjugated equine estrogen alone (Premarin™), and 147 women not on ERT/HRT
acted as comparison. Annual rates of BMD changes were calculated on a
subset of 81 women on ERT/HRT who had more than one previous BMD measured
by dual-energy X-ray absorptiometry (DEXA). Controlling for age, years
since menopause (YSM), body mass index (BMI), waist to hip ratio, and
smoking, we found that urinary estrogen metabolite levels were
significantly higher in ERT/HRT-treated women compared to those not on
ERT/HRT. Furthermore, women in the higher 2 tertiles of
2OHE<sub>1</sub> and
2OHE<sub>1</sub>/16áOHE<sub>1</sub> ratio had
positive increments in BMD compared to those in the lowest tertile who
lost bone while on ERT/HRT. Thus, women with estrogen metabolism favoring
the 2-hydroxylation pathway respond favorably to ERT/HRT. [ABSTRACT
FROM AUTHOR; Copyright 2004 Elsevier] |
| Author
Affiliations: |
1Division
of Bone and Mineral Diseases, Washington University School of Medicine,
St. Louis, MO 63110, USA
2Immuna Care Corporation,
Bethlehem, PA 18015, USA |
| ISSN: |
8756-3282 |
| DOI: |
10.1016/j.bone.2004.05.010 |
| Accession
Number: |
14250381 |
| Persistent link
to this record: |
http://80-search.epnet.com.ezproxy.libraries.wright.edu:2048/login.aspx?direct=true&db=aph&an=14250381 |
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