| Title: |
Use of low potency estrogens does not reduce the risk of
hip fracture. |
| Authors: |
Michaëlsson,
K.1 karl.michaelsson@ortopedi.uu.se
Baron,
J.A.2
Farahmand,
B.Y.3
Ljunghall,
S.4 |
| Source: |
BONE;
Apr2002, Vol. 30 Issue 4, p613, 6p |
| Document
Type: |
Article |
| Subject
Terms: |
*ESTROGEN
-- Therapeutic use
*FRACTURES
*HIP
joint |
| Author-Supplied
Keywords: |
Hip
fracture
Estrogen
Estriol
Hormone
replacement therapy |
| Abstract: |
High endogenous sexual
hormone levels and use of medium potency
estrogens are associated with a reduced risk of hip fracture in
postmenopausal women. However, it is not clear if low potency estrogens
confer the same benefits as the more widely used forms of menopausal
hormone replacement.
We examined the association between postmenopausal use of low potency
estrogens, mainly estriol, and hip fracture risk
in a population-based, case-control study. Using data from mailed
questionnaires and telephone interviews, we analyzed the association
between low potency estrogen use and hip fracture risk among 1327 cases,
50–81 years of age, and 3262 randomly selected age-matched controls. Ever
use of low potency estrogens was reported by 19% of the cases and 23% of
controls. Compared to with never users of any
hormone replacement
therapy, ever users of low potency estrogens had
a multivariate odds ratio (OR) for hip fracture of 0.96 (95% confidence
interval [CI] 0.67–1.39). Current use was also not associated with a
reduction in risk: OR 0.94 (95% CI 0.58–1.53), and longer duration of use
was also not associated with a risk reduction. Even current use of the
highest dose of oral estriol (2 mg/day)
conferred no risk reduction (OR 1.01, 95% CI 0.61–1.67) compared with
never use of hormone
replacement therapy.
After exclusion of ever users of medium potency estrogens from the
analyses, we found a risk reduction of fracture among current vaginal low
potency estrogen users (multivariate OR 0.67, 95% CI 0.49–0.92). In
contrast to medium potency estrogens, low potency estrogens did not confer
a substantial overall reduction in hip fracture risk. [ABSTRACT FROM
AUTHOR] |
| Author
Affiliations: |
1Department
of Orthopaedics, University Hospital, Uppsala,
Sweden
2Departments of Medicine and Community & Family
Medicine, Dartmouth Medical School, Hanover, NH,
USA
3Department of Epidemiology, Stockholm County Council,
Stockholm, Sweden
4Department of Internal Medicine,
University Hospital, Uppsala, Sweden |
| ISSN: |
8756-3282 |
| Accession
Number: |
7776172 |
| Persistent link
to this record: |
http://80-search.epnet.com.ezproxy.libraries.wright.edu:2048/login.aspx?direct=true&db=aph&an=7776172 |
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