Title: |
Estriol retards and stabilizes
atherosclerosis through an NO-mediated system. |
Authors: |
Kano,
Hatsuyo1 Hayashi,
Toshio1 hayashi@med.nagoya-u.ac.jp Sumi,
Daigo1 Matusi-Hirai,
Hisako1 Tsunekawa,
Taku1 Endo,
Hidetoshi2 Iguchi,
Akihisa1 |
Source: |
Life
Sciences; May2002, Vol. 71 Issue 1, p31, 12p |
Document
Type: |
Article |
Subject
Terms: |
*ATHEROSCLEROSIS *HORMONE
therapy *NITRIC
oxide |
Author-Supplied
Keywords: |
Nitric
Oxide Estriol Atherosclerosis |
Abstract: |
Estriol (E3) has little
effect on the female genitals. E3 is used in
hormone replacement
therapy, particularly in Europe and Japan, since
it obviates the need for progestin administration. However, the effect of
E3 on atherosclerosis has not been elucidated. In this study, we evaluated
the effect of E3 on the progression of atherosclerosis in a rabbit model.
Thirty-six rabbits total were used. Twenty-eight were bilaterally
oophorectomized, and 8 were not. The rabbits were divided into 5 groups
and treated for 12 weeks as follows. Gp I (n = 8) was fed a high
cholesterol diet (HCD; standard diet plus 0.5% cholesterol); Gp II (n = 8)
was fed a HCD with E3 (0.3 mg/kg/day); Gp III (n = 8) was fed a HCD with
17β estradiol (E2) (0.1 mg/kg/day); Gp IV (n = 8), the non oophorectomized
group, was fed a HCD; and Gp NC was oophorectomized (n = 4), and fed a
regular diet. E3 treatment increased the plasma E2 and E3 levels in Gp II.
The plasma lipid levels were not altered by the E2 or E3 treatment. A HCD
diminished the acetylcholine-induced NO mediated relaxation in the
thoracic aorta. The E2 treatment (Gp III) and E3 treatment (Gp II)
restored the aortic basal NO release and the aortic cyclic GMP levels,
particularly effectively in the E3 group. E3 treatment also decreased the
atherosclerotic area, and its effect was comparable with E2 (surface
involvement: 41.2 ± 5.1% in Gp I; 10.1 ± 2.7% in Gp II; and 6.5 ± 1.3% in
Gp III). All four hyperlipidemic groups showed an increase of eNOS mRNA in
the aortae, and this was especially pronounced in Gps II and III. The
level of peroxynitrite, as determined by immunohistochemical nitrotyrosine
staining, was lower in Gps II and III than in Gp I. E3 strongly activates
NO-mediated systems, and could play a role in retarding the progression of
atherosclerosis and in stabilizing atheroma. [ABSTRACT FROM AUTHOR;
Copyright 2002 Elsevier] |
Author
Affiliations: |
1Department
of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya,
Japan 2Department of Internal Medicine, National Chubu
Hospital, Oobu, Japan |
ISSN: |
0024-3205 |
Accession
Number: |
7809899 |
Persistent link
to this record: |
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