Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]
Author:
Keyword(s):
Year:  Vol:  Page: 


This Article
Full Text
Full Text (PDF)
Alert me when this article is cited
Alert me if a correction is posted
Services
Similar articles in this journal
Similar articles in PubMed
Alert me to new issues of the journal
Download to citation manager
Cited by other online articles
Google Scholar
Articles by Hayashi, T.
Articles by Iguchi, A.
Articles citing this Article
PubMed
PubMed Citation
Articles by Hayashi, T.
Articles by Iguchi, A.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 55:B183-B190 (2000)
© 2000 The Gerontological Society of America

Estriol (E3) Replacement Improves Endothelial Function and Bone Mineral Density in Very Elderly Women

Toshio Hayashia, Izumi Itoa,b, Hatsuyo Kanoa, Hidetoshi Endob and Akihisa Iguchia

a Department of Geriatrics, Nagoya University School of Medicine, Japan.
b Department of Internal Medicine, National Chubu Hospital, Oobu, Japan.

Toshio Hayashi, Department of Geriatrics, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan E-mail: hayashi{at}med.nagoya-u.ac.jp .

Decision Editor: Jay Roberts, PhD

We investigated the effects of estriol (E3) on endothelial function and bone mineral density (BMD) in very elderly women. Twenty-four very elderly women (80 ± 3.5 years old) were administered CaCl2 with or without estriol treatment (2 mg/day) for 30 weeks (hormone replacement treatment [HRT] group vs control group). Endothelium-dependent flow-mediated dilatation (FMD), endothelium-independent dilatation by nitroglycerin of the brachial artery, and BMD were assessed. Levels of plasma lipids and apoproteins were not changed; however, both plasma E3 and E2 were substantially increased (E2, 4.6 to 31.3 ± 8.1; E3, <5 to 45.3 ± 7.9 pg/mL) by HRT. The FMD value was also increased by HRT, as were the plasma nitrite/nitrate and cGMP values. The response to nitroglycerin was not changed. The BMD was increased by HRT, but decreased in the control group. There were significant differences between the HRT group and control group after 30 weeks' treatment in the levels of osteocalcin, P1CP, and urinary deoxypiridinoridine. E3 significantly improved BMD by inhibiting bone resorption. Endothelial function was improved in line with the antiatherosclerotic effects. E3 might be effective for use in HRT in elderly patients.




This article has been cited by other articles: (Search Google Scholar for Other Citing Articles)


Home page
Am. J. Physiol.Home page
R. G. Mishra, F. Z. Stanczyk, K. A. Burry, S. Oparil, B. S. Katzenellenbogen, M. L. Nealen, J. A. Katzenellenbogen, and R. K. Hermsmeyer
Metabolite ligands of estrogen receptor-{beta} reduce primate coronary hyperreactivity
Am J Physiol Heart Circ Physiol, January 1, 2006; 290(1): H295 - H303.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart JournalHome page
M. L. Bots, J. Westerink, T. J. Rabelink, and E. J.P. de Koning
Assessment of flow-mediated vasodilatation (FMD) of the brachial artery: effects of technical aspects of the FMD measurement on the FMD response
Eur. Heart J., February 2, 2005; 26(4): 363 - 368.
[Abstract] [Full Text] [PDF]


Home page
J ImmunolHome page
H.-b. Liu, K. K. Loo, K. Palaszynski, J. Ashouri, D. B. Lubahn, and R. R. Voskuhl
Estrogen Receptor {alpha} Mediates Estrogen's Immune Protection in Autoimmune Disease
J. Immunol., December 15, 2003; 171(12): 6936 - 6940.
[Abstract] [Full Text] [PDF]


Home page
J Gerontol A Biol Sci Med SciHome page
C. Christmas, K. G. O'Connor, S. M. Harman, J. D. Tobin, T. Munzer, M. F. Bellantoni, C. St. Clair, K. M. Pabst, J. D. Sorkin, and M. R. Blackman
Growth Hormone and Sex Steroid Effects on Bone Metabolism and Bone Mineral Density in Healthy Aged Women and Men
J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2002; 57(1): M12 - 18.
[Abstract] [Full Text] [PDF]


Home page
J Gerontol A Biol Sci Med SciHome page
K. K. Koh and S. H. Yang
Commentaries on "Estriol (E3) Replacement Improves Endothelial Function and Bone Mineral Density in Very Elderly Women" and Author Response: Hormone Replacement Therapy in Octogenarian Women: Good or Bad?
J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2000; 55(4): 191B - 193.
[Full Text]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
All GSA journals The Gerontologist
Journals of Gerontology Series B: Psychological Sciences and Social Sciences
Copyright © 2000 by The Gerontological Society of America.