 About Entrez
NCBI Toolbar
Text Version
Entrez PubMed
Overview
Help | FAQ
Tutorials
New/Noteworthy
E-Utilities
PubMed Services
Journals Database
MeSH Database
Single Citation Matcher
Batch Citation Matcher
Clinical Queries
Special Queries
LinkOut
My
NCBI
Related
Resources
Order Documents
NLM Mobile
NLM Catalog
NLM Gateway
TOXNET
Consumer Health
Clinical Alerts
ClinicalTrials.gov
PubMed Central |
|
|
Note: |
|
Performing your original search, minaguchi
estriol, in PubMed will retrieve 2
citations. |
| Display Show |
 |
|
|
-
Effect of estriol on bone loss in
postmenopausal Japanese women: a multicenter prospective open
study.
Minaguchi
H, Uemura
T, Shirasu
K, Sato
A, Tsukikawa
S, Ibuki
Y, Mizunuma
H, Aso
T, Koyama
T, Nozawa
S, Ohta
H, Ikeda
T, Kusuhara
K, Ochiai
K, Kato
J, Kinoshita
T, Tanaka
K, Minagawa
Y, Kurabayashi
T, Fukunaga
M.
Department of Obstetrics and Gynecology, Yokohama City
University School of Medicine, Kanagawa, Japan.
OBJECTIVES: To
assess the effects of oral estriol on the bone mineral density (BMD) and
bone metabolism in postmenopausal women. METHODS: Seventy-five natural
postmenopausal women with a BMD of more than 10% below the peak bone
density were treated for 50 weeks with 2 mg/day estriol (E3) cyclically
and 0.8 g/day of calcium lactate continuously. BMDs at L2-L4 were
measured by dual energy X-ray absorptiometry (DXA). RESULTS: The BMD
increased 1.79% (p < 0.01 vs. pretreatment) after 50 weeks,
accompanied with decrease of biochemical markers of bone turnover. With
regard to climacteric symptoms, Kupperman's menopausal index improved (p
< 0.01 vs. pretreatment) after 5 weeks of treatment. As to the
incidence of adverse events genital bleeding was observed in only 8.0%
of the subjects. Endometrial histology and cytology showed neither
abnormalities nor hyperplasia during and after the treatment.
CONCLUSIONS: Estriol prevented postmenopausal bone loss and improved
climacteric symptoms effectively with low incidence of genital
bleeding.
Publication Types:
MeSH Terms:
Substances:
PMID:
8840712 [PubMed - indexed for MEDLINE]
| Display Show |
| |