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Performing your original search, estriol succinate
oral, in PubMed will retrieve 8
citations. |
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The effect of oral estriol succinate therapy on
the endometrial morphology in postmenopausal women: the significance of
fractionation of the dose.
Punnonen
R, Soderstrom
KO.
Postmenopausal women were given estriol succinate
orally in a daily dose of 4 mg X 2 for 14 days or 4 mg X 2, 8 mg X 1 and
2 mg in the morning + 2 mg at noon + 4 mg in the evening for 4 wk. Each
group consisted of 4 women. The effect of the estrogen treatment was
estimated by the endometrial curettage samples taken both before and
after the hormone treatment. The curettage samples were studied by both
light and electron microscopy. The results showed that a treatment
period of 4 wk was necessary to obtain any effect. When 8 mg of estriol
succinate was given in a single dose only a slight effect was obtained
on the endometrium but when the same dose was divided in 2 daily 4 mg
parts, the endometrium showed clearly proliferative changes. Thus
estriol is able to produce the same endometrial effect as estradiol.
Ultrastructurally the hormone treatment caused an increase in the
cytoplasm of the endometrial epithelial cells. Also, whorls of
cytoplasmic microfilaments often appeared near the nucleus of the
cells.
PMID: 6832445 [PubMed - indexed for MEDLINE]
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